Kriterier for MCTD

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Alarcon-Segovia Diagnostiske Kriterier for Mixed Connective Tissue Disease (MCTD) (Ref: Alarcon Segovia D, Villareal M: Classification and diagnostic criteria for mixed connective tissue disease In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Elsevier, Amsterdam 1987. p.33-40)

1. Serologisk: Positive anti U1 RNP titer >1:1600

2. Klinisk:

  1. Ødema i hender
  2. Synovittt
  3. Myosittt
  4. Raynaud´s
  5. Akrosklerose (sklerodaktyli)
  • Diagnosekrav: Serologi + minst 3 kliniske punkter
  • Ved hånd ødem, Raynaud´s og akrosklerose kreves minst et annet punkt i tillegg

Mer her

Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

  1. Raynaud´s Phenomenon
  2. Swollen fingers or hands

Presence of Anti U1 RNP

Mixed findings

A. Systemic lupus erythematosus (SLE) like

  • Polyarthritis
  • Pericarditis/pleuritis
  • Lymphadenopathy
  • Facial erithema
  • Leucopenia/thrombocytopenia

B. Scleroderma like

  • Sclerodactyly
  • Pulmonary fibrosis
  • Esophageal dysmotility

C. Polymyositis like

  • Muscle weakness
  • High creatine phosphokinase (CPK)
  • Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.

Litteratur her

MCTD, BINDEVEVSSYKDOMMER.no

Palm 2015