Differential diagnosis APLS 4.67/5 (3)

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A doctor who has experience with APLS will usually make the correct diagnosis without any uncertainty. However, in special cases, the diagnosis may be difficult. The suggestions below can then be considered.

Differential Diagnoses by APLS:

  • False positive anti-phospholipid (APL) antibody tests occurs in up to 9,4% of blood donors. The diagnosis antiphospholipid syndrome (APLS) Therefore, not only blood test results are set, and the test should show changes over time. Test again after three months
  • False negative tests (no rash in the test even though APLS is present) may also be present, but are believed to be rare: antibodies to phosphatidylserine, phosphatidylinositol and prothrombin may be causes
  • Venous thrombosis:
    • Coagulopathies: Factor analyzes
    • Defects in the thrombolysis system
    • Cancer / myeloproliferative diseases
    • Nephrotic syndrome with protein loss
  • Arterial thromboembolism
  • Combined Venous and Arterial Occlusion:
    • Defective thrombolysis (dysfibrinogenemia or plasminogen activator deficiency)
    • Homocysteinemia
    • Myeloproliferative diseases
    • Polycytemia vera (hyperviscosity)
    • Paroxymal nocturnal hemoglobinuria
    •  Walden stream macroglobulinemia
    • Sickle cell disease
    • Vasculitis diseases
    • Paradoxical embolism
  • Cancer
    • Increased risk of thrombosis in known cancer disease, but also in case of unknown cancer (initial symptom before diagnosis)
      • A limited malignancy examination is recommended for thrombosis without a known cause

Unclear cause of thromboembolism


Antifosfolipid syndrome BINDVEVESSYKDOMMER.no

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