A doctor who has experience with the Antisynthetase syndrome will usually make the correct diagnosis without any uncertainty. However, in special cases, the diagnosis may be difficult. The suggestions below can then be considered.

Wrong diagnosis? Similar conditions (differential diagnoses)

• Other myopathies / Myositis / Systemic sclerosisoverlap or other connective tissue diseases and in addition idiopathic, isolated Interstitial lung disease (ILD)
  • No antisyntetase antibodies (a-Jo-1, etc.)
• MDA5 associated disease
• Interstitial pneumonia with autoimmune characteristics / features (IPAF)
• Manifestations in joints may resemble rheumatoid arthritist or Psoriatic arthritis
• Lung infection (pneumocystis og Other opportunistic infections)
• Pulmonary haemorrhage

Antisynthetase syndrome, BINDEVEVSSYKDOMMER.no

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