CellCept (mycophenolate) 4/5 (2)

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This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.

CellCept

Disease-modifying drug containing mycophenolate mofetil, tablets.

  • Most common doses: 1000-1.500 mg morning and evening. Begin with 500mg / d a few days (less gastrointestinal disorders) before rapid dose increase. The maximum dose is often 3000mg / day.
  • Calculation of dosage is done after measurements in blood serum (AUC = Area under curve)
  • Interactions
    • Aciclovir (Zovirax) increases mycophenolate (CellCept) levels in the blood
    • Proton pump inhibitors and various antibiotics reduce the effect. NB proton pump inhibitors reduce mycophenolate levels by 20-40% due to reduced absorption. Risk of mycophenolate overdose if proton pump inhibitor therapy is terminated without dose adjustment of CellCept. Check interaksjoner.no
  • The treatment must be terminated (replaced) before pregnancy
  • Individual refund is applied in Norway for individual application to HELFO on §3 (a and b combined) more: HELFO
  • Tablets that have a good effect on renal insufficiency and in some cases are used as induction instead of Sendoxan or as maintenance treatment for severe rheumatic diseases
  • Among the side effects are gastrointestinal symptoms with diarrhea, abdominal pain or nausea, most initially. Cytopenia occurs. Regular blood tests are required.
  • Follow-up
    • Cell counts every week for the first month, then every NUMX day for 14 months then monthly
    • AUC (Area Under Curve) is calculated by formula on www.anx.no Based on three measurements: C0 (drug resistant), C0.5 (30 min after drug dose) and C2 (2 hours after). Reference area (as with tacrolimus) is 30-60 for adults
  • Protection against strong sun is recommended because the medication can contribute to increased risk of skin cancer

Calculation of the correct dose via measurement in blood serum (AUC = Area under curve)

  • Samples taken
    1. Prior to drug intake (C0)
    2. After 30 min (C0,5)
    3. After 2 timer (C2)
  • AUC 30-60 is OK

Patient information


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