This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.

Imurel (azathioprine)

• Inhibit B lymphocytes
• Usually, 2,0 -2,5mg / kg / day is administered in one or two doses
• In advance mAcknowledgment of genetic disposition for intolerance to Imurel is available (TPMT measurement)
• Therapeutic range for 6-TGN (Therapeutic range 3,5-5,0) and meMP (<50 micromol / l), please see anx.no (6tgn)
• High value for 6-TGN and low for 6-MMT (<5) may indicate genetic TPMT gene variant. Consider lower dose or other treatment.
• Some people respond quickly to azathioprine with "drug fever" or DRESS syndrome, Leukopenia or liver enzyme increase and must terminate treatment.
• Leukocytopenia (low number of neutrophil leukocytes) occurs at high doses and may be difficult to distinguish from SLE activity (which may also cause leukocytopenia)
• Allopurinol / Zyloric (against uric acid) increases Imurel effect and side effects
• Can be used during pregnancy.
  • Dosage that exceeds 100mg / day should be avoided by breastfeeding because the drug passes into breast milk even if harm is not detected
• Protection against strong sun is recommended because the medication can contribute to increased risk of skin cancer

Patient information

• The Norwegian Medical Association
• UpToDate (American side)

Recommendations

Norwegian Rheumatological Association

Medications, BINDEVEVSSYKDOMMER.no

• Bindevevssykdommer.no
• Vaskulitt.no