Methotrexate Please rate this page (bottom of page)

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This page contains a brief description that does not cover the medication. For more information read the review in for the respective drug.


Methotrexate is a disease-reducing drug that is used against several types autoimmune diseases.


  • dosed ONE day in the UK
  • Combined with Folic acid 1mg / day
  • Tablets or injection
  • In adults, the dose is usually between 10mg one day a week and 25mg one day a week

Rheumatic diseases treated with methotrexate

Side effects sm may occur

  • Nausea and decreased appetite are common, usually the day after treatment
  • Methotrexate can cause side effects from the liver (check liver enzymes (AST, ALT) in blood test regularly)
    • In general, 3 alcohol units a week can be tolerated (but not all)
  • Metotrexate is excreted by the body through the kidneys (80-90%)
    • NB Reduced dosage or discontinuation of treatment if renal failure is detected
  • Treatment mustn't end before pregnancy
  • Protection against strong sun is recommended because the medication can contribute to increased risk of skin cancer
  • Control and follow-up of a specialist in collaboration with a general practitioner is recommended

Patient information


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