Freezing of sperm and egg cells (cryopreservation) in rheumatic disease Please rate this page (bottom of page)

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Freezing of sperm and eggs may be appropriate before treating some rheumatic diseases. Hungarian Wikipedia Dr. Vereczkey Attila.CC BY SA 3.0

Definition

Most types of disease-suppressive drugs (Methotrexate, Azathioprine, CellCept, Plaquenil, Biological drugs and more) against rheumatic disease (DMARD = Disease Modifying Antirheumatic Drug) does not lead to permanent impaired ability to have children (fertility). An exception is Sendoxan (cyclophosphamide) used in severe illness where internal organs, brain / nervous system and blood vessels are attacked as in some forms of Vasculitis or Systemic connective tissue diseases:. Sendoxan is a chemotherapy.

Methods

Males: Men who plan to become fathers and who need Sendoxan may be offered freezing of semen (sperm bank). The semen can later be used for fertilization. More about freezing and storage of semen here (Wikipedia )

Females: For women under the age of 35, who wish for later pregnancy, freezing of fertilized or unfertilized eggs (oocytes) can be applicable (more information here: Wikipedia ). Often the freezing of ovarian tissue (ovary) is selected methode. The procedure is surgical (laparoscopy) and ovarian tissue extraction is done at several hospitals spread throughout the country. Retention and reversal of ovarian tissue is done in Norway only at Oslo University Hospital. More about freezing of ovarian tissue Here (Oslo University Hospital).

Re-establishment of fertility after reversal of ovarian tissue may happen when chemotherapy has been completed. After surgery, pregnancy may occur after 8-18 months. In Norway, approximately 180 women have been "harvested" for ovarian tissue. Four have been recovered from ovarian tissue and two have become pregnant (per 2015). Results from Denmark (Rigshospitalet) Based on approximately 40 births indicates that about 30% of those who get recurrent ovarian tissue become pregnant and breastfeeding. Most have had cancerous diseases (breast cancer, lymphoma and other types) treated with high doses of chemotherapy and some with bone marrow transplantation (High-dose treatment with autologous stem cell support = HMAS). More about fertility- conserving treatment by ovarian freezing Here: (Norwegian National Competence Center).

Measurement of ovarian function after return

When the ovaries resume the function after successful reversal, one sees that the levels off FSH (follicle-stimulating hormone) decrease and AMH (anti-Müller-Hormone) Increases.

Literature

Medicines, BINDEVEVSSYKDOMMER.no


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