Otezla (apremilast) Please rate this page (bottom of page)

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This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.


Otezla (apremilast) are imun modulating tablets, a so-called PDE4 (phosphodiesterase inhibitor).


Otezla is used against Psoriasis (plaque psoriasis) and Psoriatic arthritis. The drug has also shown an effect against Behcet's disease (on mucous membranes). and Rheumatoid arthritis. It has been tested by Rheumatoid arthritis and Ankylosing spondylitis, but did not show safe effect (references: Genovese MC, 2015, RheumNow)


Otezla should not be used during pregnancy


  • The most common dose is 30 mg morning and evening
  • At startup, the following regimen is used: Day 1: 10 mg tomorrow. Day 2: 10 mg tomorrow, 10 mg evening. Day 3: 10 mg tomorrow, 20 mg evening. Day 4: 20 mg tomorrow, 20 mg evening. Day 5: 20 mg tomorrow, 30 mg evening. Day 6 and beyond: 30 mg tomorrow, 30 mg evening


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