This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.

Definition

Otezla (apremilast) are imun modulating tablets, a so-called PDE4 (phosphodiesterase inhibitor).

Indication

Otezla is used against Psoriasis (plaque psoriasis) and Psoriatic arthritis. The drug has also shown an effect against Behcet's disease (on mucous membranes). and Rheumatoid arthritis. It has been tested by Rheumatoid arthritis and Ankylosing spondylitis, but did not show safe effect (references: Genovese MC, 2015, RheumNow)

Pregnancy

Otezla should not be used during pregnancy

Dosage

• The most common dose is 30 mg morning and evening
• At startup, the following regimen is used: Day 1: 10 mg tomorrow. Day 2: 10 mg tomorrow, 10 mg evening. Day 3: 10 mg tomorrow, 20 mg evening. Day 4: 20 mg tomorrow, 20 mg evening. Day 5: 20 mg tomorrow, 30 mg evening. Day 6 and beyond: 30 mg tomorrow, 30 mg evening

Prescription

• H-prescription which is covered by the patient's health enterprise

Patient information

• UpToDate (American side)
• The Norwegian "Community Catalog" (Patient Edition)

Reference

• The Norwegian "Felleskatalog"

Medications, BINDEVEVSSYKDOMMER.no

• Bindevevssykdommer.no
• Vaskulitt.no