Plaquenil (hydroxychloroquine / hydroxychloroquine) 4.3/5 (10)

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This page contains a brief description that does not cover the medication. For more information read the review in for the respective drug.


Originally, Plaquenil (hydroxychloroquine / hydroxychloroquine) is a drug for malaria, but is used little because the malaria parasites have become resistant (resistant). However, the drug has shown good effect by Systemic lupus (SLE). Plaquenil is also sometimes used for other connective tissue disorders.

Chloroquine / chloroquine is related to hydroxychloroquine (Plaquenil), but has approx. 40% higher risk of side effects, without the effect being better. Therefore, against rheumatic diseases, Plaquenil is preferred (reference: Liu J, 2020).

Research in laboratories has previously suggested that Plaquenil may have a protective effect against the coronavirus Covid-19. Later research disproved this (Boulware DR, 2020). 


Tablets: 1-2 tablets (200-400 mg) daily (depending on body weight and renal function). Preferably, doses below 5mg / kg / day. Doses above 6,5mg / kg / day are not recommended.

Indication and precautions

Disease relief by Systemic lupus erythematosus (SLE) and some other connective tissue disorders

SLE (Systemic Lupus Erythematosus)

Side Effects: Eyes / sight


  • Simultaneous use of Tamoxifen (after breast cancer) increases the risk of eye-side effects (5-doubled risk)
  • Plaquenil may increase the serum concentration of ciclosporin (Sandimmun Neoral) and digoxin (a cardiac medicine)
  • Plaquenil may increase the effect of insulin and other diabetes treatments
  • Plaquenil can reduce the effect of medication against epilepsy
  • When using multiple drugs at the same time, risk interactions can be investigated via
  • Psoriasis (skin disease) can be aggravated by Plaquenil (reference: Wolf R, 1999)

Patient information

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