Tuberculosis screening before immunosuppressive treatment Please rate this page (bottom of page)

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TNF inhibitors, several other types Biological drugs og Janus Kinase (JAK) inhibitors Is shown to decrease the immune system So latent Tuberculosis (Tbc) (bacteria from previous infection) may flare up. Corresponding risk is also available when using high doses of corticosteroids (Prednisone, SoluMedrol and others). IGRA test (Blood test) is central to detect latent Tbc.

Prior to treatment with TNF inhibitors

  • Targeted disease history on Tbc
  • Complete clinical examination
  • X-ray of the lungs or CT (computer tomography) of the lungs
  • Tuberculin test or IGRA test
  • Refer to a specialist in lung diseases or infectious diseases if
  • Preventative treatment for Tbc (Isoniazid or Isoniazid in combination with rifampicin) should usually be stopped before starting treatment with a TNF-antagonist, but is sometimes given with the anti-rheumatic treatment
  • Preventative treatment is no guarantee of later tuberculosis

 Symptoms of Tbc

Source: The Norwegian Public Health Institute


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