TAFRO syndrome on PET / CT. Nagano M, Matsumoto J - Surg Case Rep (2016). CC BY 4.0

Definition

TAFRO Syndrome is a variant of multi cents rice Castleman's disease and is identified in Japan. It is described among middle-aged and elderly people, rarer among young people. The syndrome consists of:

• Thrombocytopenia (low platelet count)
• Anasarca (Body fluid)
• Reticulin fibrosis in bone marrow (biopsy)
• Renal function is reduced
• Organomegaly (large organs)

TAFRO may occur with other diseases, including autoimmune rheumatic diseases, infections and cancer.

Treatment

The treatment consists of immunosuppressive drugs.

Literature

• Kawabata H, 2013
• Konishi Y, 2015

• Bindevevssykdommer.no
• Vaskulitt.no