Sarcoidosis often manifests itself in several organs, such as lungs, skin, joints / skeleton, heart muscle and eyes. Symptoms and examination findings there may be similar to several other conditions. The list of differential diagnoses (similar conditions) is therefore long. Which of the conditions is most relevant is decided in each individual case based on the development of symptoms and examination findings.
Contents
SAROIDOSIS IN LUNGS
Enlarged lymph nodes in the lung hilus
Cancer
- Primary lung cancer (lung cancer)
- Non-Hodgkin's lymphoma
- Primary mediastinal large-cell B-cell lymphoma
- Kaposi Sarcoma
- Metastases from other cancerous diseases
Other illness
Infections
- Pneumonia (pneumonia)
Swelling In mediastinal lymph nodes by inflammatory Interstitial Lung Disease (ILD)
Swollen salivary glands
- Sjögren's syndrome
- IgG4 related disease
- Mikulicz syndrome
- Cuts tumor
- Salivary gland stones
- Infections
Chronic obstructions in both lungs, bilateral interstitial lung disease (ILD)
- Inflammatory (inflammatory)
- Infections
- Tuberkulosis (Tbc)
- Mumps infection, especially when weakened immune system
- Infection that is incompletely treated
- Leprosy
- Cancer / lymphoproliferative diseases
- Lymphomas
- Lymphoid interstitial pneumonia (LIP), often at Sjögren's disease
- Bronchoalveolar Carcinoma (BAC)
Occupational-related pulmonary disease
- Silicosis (stone industry)
- Pneumoconiosis (coal mines)
- Berylliosis (Melting of Beryllium used in fluorescent lamps and neon lamps and within spacecraft, cases of criminally infected poisoning)
- Aluminium
- Talcum / Talc (baby powder, airbags in cars)
Other
- Lipoid pneumonia
- Residual pulmonary edema
- Alveolar proteinosis
- Eosinophil Granuloma (Histiocytosis X)
- Orofacial granulomatosis
- Thin tissue in the mouth, on the lips and around the mouth
- Hypersensitivity pneumonitis
Egg shell calcifications in the mediastinum or thorax
- Definition (Jacobsen and Felson, 1967)
- Makes up approx. 5% of all sarcoidosis cases
- Shell-like calcifications up to 2mm in thickness at the outer edge of at least two lymph nodes
- The lime may be uniform or crumbled
- Ring-shaped lime structure in at least one lymph node
- In addition to the central lymph node, it may be lime
- At least one lymph node must be at least 1cm in the largest diameter
- Besides of sarcoidosis
- Silicosis (5%)
- After radiotherapy of Hodgkin's lymphoma (1-9 years later)
- Pneumoconiosis (coal miners)
- Systemic sclerosis
- Amyloidosis
- Blastomycosis (North America)
- Histoplasmosis (USA, Canada, East Africa, India)
- Similar changes
- Aneurysms
- Parathyreoidea tumors
- Lung arteries at Pulmonary hypertension
- Thymus cysts
Sarkoidosis of the skin
Erythema nodosum, other causes
- Please see dedicated page here (in Danish) (Vaskulitt.no)
- Idiopathic (unknown cause) 50%
- Pregnancy
- Infections
- Tuberkulosis (Tbc)
- Yersinia intestinal infection
- Streptococcus
- Epstein-Barr virus (EBV)
- Mycoplasma pneumoniae
- inflammation
- Crohn's disease
- Ulcerative colitis
- Behcet's disease
- Takayasu arteritis
- Medication
- Sulphate preparations (sulfonamides)
- Penicillin
- Hepatitis B vaccine
- Cancer
- Lymphoma (Non-Hodkgins)
- Pancreatic cancer
- Carcinoid tumor
Lupus pernoi
Joint and skeleton
- Arthritis
- Osteoarthritis
- Metastasis (Back / Skeleton)
- Myeloma (Back / Skeletal)
- Eosinophilic granuloma
Heart
- Heart failure or cardiac arrhythmias for other reasons
- Cardiomyopathy (granuloma and proximal septum)
- Myxoma (atrial granuloma)
- Pulmonary hypertension
- Amyloidosis
- Other heart disease
The eye
- Other causes of granulomatous uveitis / iritis
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