
GVDH, chronic skin reaction with pigment changes. Vasconcelos L, 2013. CC BY NC 3.0
Contents
Graft versus host disease (GVHD), (ICD-10: T 86.0)
Definition
Transplanted organs (bone marrow, kidneys, heart and others) from another person can activate the immune system to cause symptoms and illness. A similar reaction can occur after contact with other foreign substances. GVHD gives similar symptoms rheumatic connective tissue disorders, but is often investigated and treated by immunologists.
- GVHD is defined acute rejection reaction when it occurs within NUMX days, later as chronic GVHD Graft-vs-Host Disease
Symptoms
Symptoms from stomach and intestines, skin and fever are most common (24%). Only skin symptoms in 15%. Liver and skin manifestations at 7%. Only liver symptoms of 4%
- Skin symptoms
- Rashes on neck, ears, shoulders palms and soles
- "Tanned" skin
- Blisters and rashes all over the body are more severe symptoms
- Dry mouth and dry eyes (Sjögren's syndrome-like)
- Gastrointestinal (gastrointestinal)
- Diarrhea
- Abdominal pain
- Nausea
- Lever
- Liver enzymes in the blood are rising
- ALP and conjugated bilirubin rise first
Incorrect diagnosis? (Similar diseases / differential diagnoses)
- Side Effects of Drugs
- Skin
- Eczema triggered by medication
- Virus infections
- Gastrointestinal
- Infections (Clostridium difficile, CMVreactivation)
- Liver: Viral hepatitis (Hepatitis B, Hepatitis C)
- Myositis / Dermatomyositis
- Sjögren's syndrome
- Systemic lupus erythematosus (SLE)
Treatment
- Corticosteroids (reference: Goker H, 2001)
- Experimental other treatment (reference: Murata M 2015)