GVHD, Graft versus host disease, rejection reaction 4/5 (2)

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GVHD

GVDH, chronic skin reaction with pigment changes. Vasconcelos L, 2013. CC BY NC 3.0

Graft versus host disease (GVHD), (ICD-10: T 86.0)

Definition

Transplanted organs (bone marrow, kidneys, heart and others) from another person can activate the immune system to cause symptoms and illness. A similar reaction can occur after contact with other foreign substances. GVHD gives similar symptoms rheumatic connective tissue disorders, but is often investigated and treated by immunologists.

  • GVHD is defined acute rejection reaction when it occurs within NUMX days, later as chronic GVHD Graft-vs-Host Disease

Symptoms

Symptoms from stomach and intestines, skin and fever are most common (24%). Only skin symptoms in 15%. Liver and skin manifestations at 7%. Only liver symptoms of 4%

  • Skin symptoms
    • Rashes on neck, ears, shoulders palms and soles
    • "Sunburned" skin
    • Blisters and rashes all over the body are more severe symptoms
  • Dry mouth and dry eyes (Sjögren's syndrome-like)
  • Gastrointestinal (gastrointestinal)
    • Diarrhea
    • Abdominal pain
    • Nausea
  • Lever
    • Liver enzymes in the blood are rising
    • ALP and conjugated bilirubin rise first

Incorrect diagnosis? (Similar diseases / differential diagnoses)

Treatment

Literature


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