reticulohistiocytosis 4.25/5 (4)

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Multicentre reticulohistiocytosis. Saba R, Case Rep Rheumatol (2013). Open


Reticulohistiocytosis is a rare form of histiocytosis. The symptoms vary from some skin changes (limited form) to severe disease in many organs (multi-centric type).

Limited reticulo-histiocytosis

Only the skin is attacked

  • Synonyms: "solitary reticulohistiocytosis" or "solitary histicytoma"
  • Surgical treatment is most often curative

Multicentre reticulohistiocytosis

Synonym: "lipoid dermatoarthritis", "giant cell reticulo-histocytosis" which is an aggressive disease. Adults around the age of 50X often become ill. Only a few hundred cases are described.

Differential diagnosis


Immunosuppressants like Prednisone, Methotrexate, Azathioprine or TNF inhibitors (Biological drug)


Spontaneous recovery may occur, but relapse occurs



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