Kikuchi-Fujimoto disease 4.5/5 (2)

Share Button

Kikutchi-Fujimoto disease with swollen lymph node on the neck. Khadanga S, 2014. Openi, CC BY NC SA 3.0

KIKUCHI-FUJIMOTO disease (histiocytic necrotizing lymphadenitis)


Kikutchi-Fujimoto Disease (KFS) is a rare, benign, necrotizing lymphadenopathy (lymph node disease), most often on the neck of young women. Histology (tissue examination in biopsy) separates from cancer: histiocytic necrotizing. Unknown cause. The disease is in some cases associated with Systemic lupus erythematosus (SLE).


Most are young women, the disease can also affect men. Typically under 40 years of age at onset, but reported between 6 - 80 years of age. The average age at onset is 30 years.


  • Swollen lymph nodes on the neck (100%, 1 - 2 cm in diameter, up to 7 cm described)
  • Fever (30-50%, 1-4 weeks) at debut
  • Night sweats
  • Dizziness
  • Headache
  • Vomit
  • Diarrhea
  • Weight Loss (10%)
  • Rash
  • Arthritis (5-7%)
  • Large liver and spleen (hepatosplenomegaly) (3%)
  • Bone marrow: Increased number of macrophages, no atypical cells
  • SLE Association occurs, but ANA test is usually normal

Medical examination

Blood tests

  • Many have normal samples. Low white blood cell count (Leukopenia, in 20-32%, Blood drop reaction (SR) over 60mm in 40 - 70%, anemia in 23%)

Tissue test (biopsy) is crucial for the diagnosis


Lymph node biopsy (different from lymphoma: Hodgkins, non-Hodgkins).

  • Thin needle biopsy can be used. immunohistochemistry
    • CD68 + T lymphocytes are detected
    • Absence of neutrophils in the "necrotizing phase" differs from SLE

CT examination of swollen lymph nodes shows perinodular infiltration (81%), homogeneous contrast recording (83%)

Incorrect diagnosis? (Similar diseases / differential diagnoses)

Treatment / follow-up

No specific therapy. For severe symptoms can corticosteroids (Prednisone) be useful.

Check to exclude SLE development after a few years.


Self-limiting disease. Spontaneous decline after 1 - 4 months.


This page has had 1 visits today

Please rate this page