MBL deficiency, Mannose binding lectin deficiency 4.4/5 (5)

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Mannose binding lectin (MBL) deficiency (ICD-10 D84.8)

Definition

MBL is an acute phase protein. Some people have persistently low MBL values ​​in the blood, which increases the risk of more serious infections, especially meningococcal disease. MBL deficiency increases the risk of thromboembolism (blood clots).

Occurrence

About. 5% of the population has MBL deficiency

Clinical significance

MBL deficiency does not cause disease itself, but can increase the severity of infections. Also the course of autoimmune diseases (connective tissue disease and vasculitis) can be affected.

Treatment

No specific treatment. Preventive measures against infection (vaccines, scabies, antibiotics) are relevant. Substitution with immunoglobulins at low blood IgG values.

Literature


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