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Alarcon-Segovia Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD) (Reference: Alarcon Segovia D, Villareal M: Classification and diagnostic criteria for mixed connective tissue disease In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Elsevier, Amsterdam 1987. p.33-40)

1. Serological: Positive anti U1 RNP titer> 1: 1600

2. Clinical:

  1. Edema in hands (puffy hands)
  2. Synovitis
  3. Myositis
  4. Raynaud's phenomena
  5. Acrosclerosis (sclerodactylia)
  • Diagnostic requirements: Serology + at least 3 clinical points
  • By hand edema (puffy hands), Raynaud's and acrosclerosis are required at least another point in addition

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Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

  1. Raynaud's Phenomenon
  2. Swollen fingers or hands

Presence of Anti U1 RNP: Mixed findings

A. Systemic lupus erythematosus (SLE) like

  • Polyarthritis
  • Pericarditis / pleuritis
  • Lymphadenopathy
  • Facial erythema
  • Leucopenia / thrombocytopenia

B. Scleroderma alike

  • Sclerodactylia
  • Pulmonary fibrosis
  • Esophageal dysmotility

C. Polymyositis alike

  • Muscle weakness
  • High Creatine Kinase (CK)
  • Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.

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