MDA-5 antibody syndrome 4.25/5 (4)

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Anti MDA5 Myositis Syndrome

MDA5 related dermatomyositis. Parronchi P, Clin Mol Allergy (2015). CC BY 4.0


A form of Dermatomyositis, but the muscle inflammation is little pronounced ("amyopathic dermatomyositis"). On the other hand, pulmonary symptoms are often severe. Everybody has antibody MDA5 although ANA is usually negative / non-existent.


Blood tests


  • Typical lung abnormalities (Ground glass opacities)
  • MDA5 antibody
  • Absence of other explanations

Incorrect diagnosis (similar conditions, differential diagnoses)


  • Corticosteroids in high doses
  • Mycophenolate (CellCept) 2-3 g / day
  • Tacrolimus 2-3,5 mg / day and serum levels 4-7μg / L. Tacrolimus is combined with mycophenolate (2 g / day) as needed
  • Sendoxan intravenous (pulse) is an alternative


  • Survival is individual and dependent on rapid treatment
  • Survival 60-70%
  • Deaths most often within 6-12 months from diagnosis


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