Muscle Diseases 4.5/5 (8)

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Muscle diseases originate from the muscle cells. CC BY-SA 3.0,


Muscular diseases are attacking muscle cells so that the force is weakened. Women, men and children of all ages can be attacked. The different muscle diseases are distinguished by different symptoms, examination findings, treatment and prognosis. Muscle diseases are distinguished from nerve diseases which can also lead to reduced muscle function, but the cause is damage to the nerves that are supposed to activate the muscles. Examples of such nerve diseases are Multiple sclerosis (MS), Myastenia gravis, Amyotrophic lateral sclerosis (ALS) and Parkinson's disease. Chronic muscle pain that persists for months does not have to be an expression of muscle disease. Fibromyalgia is such a condition that causes a lot of pain and stiffness in almost all muscles in women. In older people can Polymyalgia rheumatica cause sudden, severe pain and stiffness with concomitant signs of inflammation (please see below on this page). Gradually increasing stiffness, muscle pain and other rheumatic ailments can be part of the normal aging process. Please read more about aging and rheumatic symptoms here.

Different muscle disease


Medical history is important to distinguish different types of muscle disease. Muscle disease in the immediate family, age at onset of symptoms, rapid (days) or slow (weeks-years) development are important. Prior travel abroad, injury, hard training, medication and alcohol intake are also important information.

Ved survey assess whether the muscles are of normal size and strength, whether they are painful or tight. Symptoms from other organs are also examined.

In blood tests er creatine kinase (CK) elevated by polymyositis, Dermatomyositis, Muscular Dystrophy and especially by rhabdomyolysis. CK is a enzyme which originates from muscle cells. The higher the rash in the CK, the more widespread muscle damage must be assumed to be present. After physical exercise and a similar load, the values ​​also rise, but they then return to normal after a few days. Electrolyte and hormone disorders are also detected in blood tests. By Fibromyalgia og Polymyalgia rheumatica is CK normal. In myositis, rashes are often also seen antinuclear antibody (ANA) and associated subgroups are often found. In some cases, these subgroups may indicate an increased risk of developing special complications. An example is the anti-Jo-1 antibody, which requires further lung examinations. On suspicion of heredity Muscular Dystrophy or metabolic muscle diseases / storage diseases, genetic assessment and associated tests are performed

Imaging. MRI examination of affected muscles can help to distinguish the various muscle diseases. In addition, MRI changes can locate areas where it is appropriate to take a tissue sample (biopsy) from. CT of the lungs may be relevant if concomitant lung manifestations are suspected.

Vev sample (biopsy) from the attacked muscle is always an important examination in the investigation of serious muscle disease. By microscopic examination and other tests via the tissue sample, hereditary myopathies can be distinguished from myositis, rhabdomyolysis and metabolic muscle diseases.

Other investigations: Wood electromyography (EMG) og neurography Signals from muscles and nerves may show different responses, depending on the underlying cause of the disease, but the tests alone are not sufficient to make a definite diagnosis.

Similar conditions, differential diagnoses


To provide proper treatment, diagnosis of type of muscle disease is essential. The treatment is described under the individual diagnoses.


The prognosis are very different between the various diseases, in part, also depending on the response and tolerance of the treatment. For more information, see articles about the different diseases.


Hereditary muscular dystrophies are usually investigated and treated by specialists in pediatric diseases or in adulthood by neurologists. Myositis is in the field of rheumatology. Metabolic and hormonally induced muscle diseases are most often managed by endocrinologists. Other muscle diseases and pain conditions are assessed and followed by other specialists or general practitioners, depending on the severity. If necessary, close collaboration between specialist, GP, possibly other therapists and the patient is always important.

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