Cytomegalovirus (CMV) and Rheumatic Disease 5/5 (3)

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CMV human cytomegalovirus (HCMV / HHV-5). The virus belongs to the herpes virus group. It occurs latently in the body of 40-80% healthy individuals and produces no symptoms. The mechanism of infection is not fully understood, but can be via saliva and other body fluids.

  • CMV infection can be severe in a weakened immune system or during immunosuppressive antirevative therapy, after organ transplantation or in HIV infection


The disease picture may look similar Infectious mononucleosis. CMV may be suspected if the mononucleosis test is negative

  • Fever
  • Influenza-like
  • May last as mononucleosis (5% of monunucleosis cases)
  • Pneumonia (pneumonia)
  • Vasculitis in the CNS (similar to Primary CNS vasculitis)
  • Neutropenia (low number of white blood cells)


Infection in pregnancy can lead to malformations


  • PCR examination of CMC DNA after Bronchial lavage, in urine, blood, spinal fluid or amniotic fluid
  • Antigen in blood test
  • Histology (tissue examination, biopsy)
  • Antibody to CMV (IgG) remains positive throughout life after infection


Ganciclovir (Cymevene) or other potent antiviral agents


Opportunistic infections,

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