Cryptococcal infection and rheumatic disease Please rate this page (bottom of page)

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Definition

Cryptococci are fungi (Cryptococcus neoformans, Cryptococcus gattii) that rarely cause infection.

  • In case of a weakened immune system such as during immunosuppressive, anti-rheumatic treatment, after organ transplantation or by the wood HIV infection, however, severe infection can develop
  • The infection does not cause rheumatic symptoms

Disease Cause

Cryptococcus neoformans are inhaled into the lungs. It is unknown why the central nervous system (CNS) with the brain is attacked frequently.

Symptoms

  • The initial infection of the lungs usually gives no symptoms
  • Meningitis (meningitis)
    • Diffuse symptoms often cause weeks to months before diagnosis is made
  • Fever
  • Headache
    • Encephalitis = neurogenic symptoms of brain nerves, ataxia, tremor, decreased sensitivity, mental change. Hemiplegia. hearing Loss

Inflammation of the brain and brain

Meningoencephalitis is the most common manifestation. Cryptococcus is a Opportunistic infection by immunosuppressed and HIV.

Diagnosis

  • Symptoms:
    • Focal neurological paralysis in brain nerves, ataxia, tremor, hemiplegia, deafness.
  • MRI or CT examination of the brain is done before spinal puncture (possibly increased pressure /hydrocephalus at CNS affection)
  • Lumbar puncture (after CT or MRI examination of the brain)
    • Cerebrospinal fluid: Antigen test can be read immediately. Cultivation has 90% sensitivity, but takes 3-5 days. Cerebrospinal fluid is examined with "India Ink" (ink) (50% sensitivity). Opening pressure at puncture is increased. NB Hydrocephalus may cause shunting. Mononuclear cells, not necessarily elevated cell numbers, low glucose or elevated protein. Cultivation from bronchial fluid, blood cultures, and urine.

Treatment

  • Untreated, the disease is fatal
  • Combine amphotericin (0,5-0,7 mg / kg / d) and flucytoin (100-150mg / kg / d) over 2 weeks

Literature

Opportunistic infections, BINDEVEVSSYKDOMMER.no


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