Eczema by Parvovirus B19 that triggered Marophagic Activation Syndrome (MAS). Soldo-Juresa D, 2015. CC BY 2.0

Definition

Parvovirus B19 does not cause a classic ”Opportunistic infection"but important to consider among people who get immunosuppression. Parvovirus B19 Causes Rash (Erytema infectiosum), The so-called 5. childhood disease among young children.

• In addition, infection can cause significant Joint pain (arthralgia)

Symptoms

Debut

• Flu-like symptoms
  • Fever
  • Tiredness
  • Headache
• Muscle pain (myalgia)
• Cold
• Itching
• Blood: Low blood cells: anemia, leukopenia, thrombocytopenia

The following week

• Rash (rubella-like, less typical in adults than in children (erytehma infectiosum)
• Joint pain (arthralgia)
  • Among children with Erythema infectiosum, about 10% gets joint pain which can also be the only symptom of the infection
  • Adults can get one arthritis-like (RA) prevalence with pain and swelling in many joints, including finger joints.
  • The joint pain returns by itself within three weeks, less often after a few months.

Associations and Complications

• The 5. childhood disease (erythema infectiosum)
• Joint pain and arthritis
• Infection in pregnancy:
  • Non-immune Hydrops fetalis Intrauterine fetal death or spontaneous failure
• Transient aplastic crisis (too low blood cell count) in chronic haemolytic disease
• Chronic low hemoglobin in immunosuppressed patients
• Red and painful hands and feet
  • Blisters and later flaking of skin occur
  • Duration 1XX weeks
• Myocarditis and dilated cardiomyopathy
• Macrophage activation syndrome (MAS) / HLH

Literature

• Soludo-Juresa D, 2015
• Heegaard ED, 2002
• Naides SJ, 1998
• Wikipedia

• Bindevevssykdommer.no
• Vaskulitt.no