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Orisild (sildenafil) tablets 20mg

This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.


Orisild contains sildenafil, which is also the active ingredient in Revatio and Viagra. In rheumatology, Orisild tablets are used against high pressure in the pulmonary artery (pulmonary arterial hypertension / PAH) and (outside approved indication) to improve finger ulcers (digital ulcers). These are complications seen by systemic sclerosis (scleroderma).

The tablets work by inhibiting the enzyme cGMP-specific phosphodiesterase type 5 (PDE5 inhibitor).

Before starting treatment

Orisild should not be used concomitantly with nitroglycerin (which is receiving angina pectoris), not for severe liver disease, significant low blood pressure, recent stroke or heart attack.

Orisild may increase the risk of bleeding when used with Marevan  

To assess efficacy (after, for example, 3 months of treatment), measurements at baseline and a desired, defined treatment goal are important.

Pregnancy and breastfeeding

Orisild should not be used during pregnancy (fertile women must use safe contraceptive methods). Please read information about pregnancy in rheumatic diseases on a separate page here


The dosage in adults is usually 20 mg tablet morning, noon and evening


Side effects

Side effects are common, and the risk must be compared with the indication for treatment. Common side effects:

  • Blush
  • Muscle pain
  • Leg and arm pain
  • Low blood percentage (anemia), low number of white blood cells and platelets.
  • Diarrhea
  • Dry Mouth
  • Fever
  • Night sweats
  • Hair Loss
  • Dizziness
  • Anxiety

Checks and follow-up

Medical examinations after starting treatment should rule out signs of side effects and then whether the effect is as desired. Later the doctor continuously assess whether the treatment should continue. Completed treatment (discontinuation) should be done gradually.

For more information is recommended Felleskatalogen.no

- Medications for rheumatic diseases


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