The PVP syndrome of substance abuse 4/5 (1)

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PVP syndrome (polyvinylpyrrlidone) is a deposition disease caused by injected methadone tablets. Occurs among former or current drug addicts. Methadone Martindale as a release drug is taken from the market. The symptoms can be similar systemic connective tissue disease with skin manifestations, inclusive Systemic lupus (SLE), (but without Antibodies).

Disease Cause

Intravenous drugs and PVP syndrome. Illustration: Ulrich Bendele Wikimedia Commons

Polyvinylpyrrolidone (PVP) is not absorbed when taken as tablets, but by injection it is stored (accumulating) as PVP in bone marrow, kidney, gastrointestinal and skin.



Tissue samples (biopsy) from the bone marrow, kidney, gastrointestinal or skin show PVP-containing macrophages


PVP does not break down in the body, and no special treatment is available.


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