Investigation Checklist, Sarcoidosis 2.67/5 (3)

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Disease history

  • Debut Age 10-40 Year (80%)
  • Pulmonary symptoms
    • Irritant cough
    • Dyspnea
    • Pain in the lung area
  • General health status
    • Night sweat / some fever
    • Exhaustion
    • Weight Loss
  • The eye (5-20%) (Eyelid)
    • Anterior uveitis (iridocyclitis or iritis)
    • Posterior uveitt (chorioretinitt)
    • Retinal vasculitis
    • Keratoconjunctivitis
    • Conjunctive follicles
  • Skin (25%)
  • Enlarged lymph nodes
  • Hepatosplenomegaly
  • Heart failure and / or rhythm disturbances

Examinations

  • Auscultation of lungs
    • Crepitations over the lungs
  • X-ray examination or CT examination of lung
  • Lung function tests including DLCO
  • PET / CT can map different organ affection
  • Heart
    • Auscultation
    • ECG
    • MRI examination of the heart with contrast agent (gadolinium)
    • Echocardiography (left ventricular failure with EF <40%)
      • Granuloma of proximal septum (may be misinterpreted as hypertrophic cardiomyopathy), atrial graumomas may resemble myxoma (Reference Vikse J, 2018)
  • Blood tests
    • Blood sedimentation rate (ESR) and CRP (moderate increase)
    • Leukocytes (Leukopenia 5-10%)
    • ACE (high in generalized disease)
      • Reference area (adult 20-100, child 9-13 years up to 40% higher: 20-140 at OUS laboratory)
    • IgG (low at 80%)
    • Calcium (increased)
    • Calcium in urine (increased)
    • Alkaline phosphatase (increased) and liver enzymes

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