Diagnosis / Suspected SLE is based on

Disease history (check SLICC criteria below)
Medical investigation and findings
Laboratory tests
Tissues from kidneys (kidney biopsy) if kidney involvement
SLE begins most commonly in women of childbearing age, more often among people from Asia and Africa
Differential diagnoses, please see here

Disease history (anamnesis) at SLE (Syndrome)¹included in SLICC criteria, ²ACR criteria)

Time of
- Disease debut
  - Diagnosis and debut symptoms
¹Acute or chronic skin changes (eczema)
^1,2Frequent mouth ulcer
¹Alopecia (stinging hair loss)
^1,2Arthritis (small joint is most common)
^1,2Serotonitis (pleuritis, pericarditis)
^1,2Kidney disorders (proteins and blood in the urine by glomerulonephritis)
^1,2Neurological (cramps, psychosis)
^1,2blood Cells
- Hemolytic anemia (high LD and reticulocytes, low haptoglobin)
- Leukopenia
- Thrombocytopenia
^1,2Antibodies
- ANA
- DNA
- Sm
- Antifosfolipid antibodies (Lupus Anticoagulant, Cardiolipin, Beta-2-Glycoprotein)
* Low complement factors
- C3 and / or C 4
²Butterfly Rash (on the cheeks) **
²Diskoid rash**
²Sun rash (Photosensitivity **

Affected general condition: Night sweat / subfebril / fever?
Antifosfolipid syndrome (Secondary)
- Thromboses: venous and arterial?
- Miscarriages?
Joint
- Yesccoud joints (with errors) (2%)
- Erosive Arthritis (Usurer) (5%)
Heart
- Endocarditis (Libman-Sacks)
- Pulmonary hypertension (rarely at SLE)
Nervous System
- Central nervous (CNS) affection:
  - Headache/Cognitive disorders/ Apoplexy / Epilepsy /
  - Findings in MRI and MRI Angiography, SPECT, PET / CT
  - Polynesia / Peripheral pares
Dry mucous membranes
- Sicca phenomena (Secondary Sjögren's syndrome)
Raynaud's phenomenon?
Autoantibodies
- RNP (MCTD?)
- SSA / B (subacute cutaneous lupus, primarily Sjøgrens syndrome?)

The sedimentation rate (ESR) is often high
CRP almost normal, but increases with infection, arthritis and pulmonary (pleurisy) or heart bag inflammation (pericarditis)
Cell counts (Hemoglobin, lymphocytic leukocytes, platelets)
Complement factors C3 and C4
Urine with signs of glomerulonephritis (proteins, blood, protein / creatinine, cylinders)
Blood tests that take initially, then rarely
- Antibody samples (in blood) ANA, ENA, DNA antibody, anti C1q
- Antifosfolipid antibodies (Lupus anticoagulant via hematological / coagulation laboratory), α-cardiolipin and beta-2 glycoprotein (β-2GP).

All patients with aktiv SLE should be followed up by both a specialist and a GP
The frequency of controls will depend on the disease activity, complications and medications used
If new symptoms, check keywords for medical history (see above)
Clinical examinations as mentioned above
Blood and urine are checked
- Antibody and complement factors need not be checked every time
By pregnancy close monitoring of rheumatologists and obstetricians should be organized as soon as possible
Validated targets for disease activity can be done at SLEDAI

0 Nydalen, 0424 OSLO. The ward can also receive patients from the rest of the country when the capacity allows it.

This page has had 1 visits today