Pill and SLE Please rate this page (bottom of page)

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Birth control pills

In a stable, quiet disease phase, common low-estrogen combination pills can be used in uncomplicated SLE, since in a quiet disease phase they hardly worsen the disease, but an individual risk assessment is recommended

Caution with the following conditions:

  • It is important that combination pills are not used if so-called antiphospholipid antibody (lupus anticoagulant, anti-cardiolipin or beta-2 glycoprotein) in high titer in blood samples or other risk factors for thrombosis  (reference: Sammaritano LR, 2014)
  • Factor V Leiden mutation
  • Active nephritis (renal inflammation)
  • Uncontrolled hypertension (high blood pressure)
  • Active vasculitis
  • Previous thrombosis
  • Heart or lung disease
  • Migraine
  • Epilepsy
  • Among smokers

Alternatives: Gestagen pill Conludag or Cerazette ("Minipills"), progesterone as a depot (Depot-Provera) / P syringe, p-rod, hormone coil, emergency contraception / attack

Postmenopausal estrogen supplement

May increase the risk of relapse of SLE, but rarely severe. Not recommended if SLE disease is active or antiphospholipid antibody is present.

  • It is advisable to weigh the benefits against risk in each case.


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