Disease criteria for research (ACR criteria, 1980)
The main criterion is: hard skin on the fingers or toes (scleroderma proximal for MCP / MTP) or two of:
1.Sclerodactylia (hard skin on fingers)
2. Wound (ulcer) or tissue loss (atrophy) on the fingertips
3 increased scar tissue in parts of both lungs (bilateral basal pulmonary fibrosis)
New criteria (ACR-EULAR 2013) is more complicated, but more accurate (Sensitivity 91%, Specificity 92%):
Classification criteria. 2013 (reference: Van den Hoogen F) (At least 9 scores for diagnosis):
Score (weighting):
Sclerodactylia on fingers and proximal for
MCP joints (both hands) 9
Puffy fingers 2 or
Sclerodactyly of at least one full finger distal to MCP 4 (select highest score)
Ulcerate on finger pulp 2 or
Pitting scars / scars / crusts on fingertip 3 (select highest score)
Teleagiektasi 2
Capillary capillaroscopy 2
Pulmonary hypertension and / or interstitial lung disease 2
Raynaud's phenomenon 3
Antibody related to Systemic Sclerosis:
(CENP, SScL70, RNA Polymerase III) 3
