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Volibris (ambrisentan) tablets 5 mg and 10 mg

This page contains a brief description that does not cover the medication. For more information read the review in Felleskatalogen.no for the respective drug.


Volibris contains ambrisentan are tablets against high pressure in the pulmonary artery (pulmonary arterial hypertension / PAH). This is a complication most often seen in rheumatic diseases systemic sclerosis (scleroderma).

The tablets work by inhibiting endothelial receptor and are thus one endothelial receptor antagonist (ERA).

Before starting treatment

Volibris should not be used in moderate-severe hepatic impairment, for example if ALT is more than 3 times the normal limit.

Volibris should not be prescribed for pulmonary fibrosis (which may be present in systemic sclerosis). Opsumit (macitentan) is then an alternative.

Volibris should not be combined in months Ciclosporin A (Sandimmun Neoral).

To assess efficacy (after, for example, 3 months of treatment), measurements at baseline and a desired, defined treatment goal are important.

Pregnancy and breastfeeding

Volibris should not be used during pregnancy (fertile women must use safe contraceptive methods). Please read about pregnancy in Rheumatic Disease here


The dosage is usually 5 mg tablet once daily, but can be increased to 10 mg daily if needed


  • Volibris is an expensive drug, but has a lower price than macitentan (Opsumit) and is prescribed by a specialist and at H-prescription

Side effects

Side effects are common, and the risk must be compared with the indication for treatment. Common side effects:

  • Fluid retention in the body (edema),
  • Low blood percentage (anemia), low number of white blood cells and platelets.
  • Diarrhea
  • Itchy rash
  • Some experience nasal congestion
  • Headache

Checks and follow-up

Medical examinations after initiation of therapy should rule out signs of side effects that include signs of liver damage, falling hemoglobin and whether the effect is as desired. Later the doctor continuously assess whether the treatment should continue

For more information is recommended Felleskatalogen.no

- Medications for Rheumatic Disease

-Binding tissue diseases.no

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