Alarcon-Segovia Diagnostiske Kriterier for Mixed Connective Tissue Disease (MCTD) (Referanse: Alarcon Segovia D, Villareal M: Classification and diagnostic criteria for mixed connective tissue disease In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Elsevier, Amsterdam 1987. p.33-40)
1. Serologisk: Positive anti U1 RNP titer >1:1600
2. Klinisk:
- Ødema i hender (puffy hands)
- Synovitt
- Myositt
- Raynaud´s fenomen
- Akrosklerose (sklerodaktyli)
- Diagnosekrav: Serologi + minst 3 kliniske punkter
- Ved hånd ødem (puffy hands), Raynaud´s og akro-sklerose kreves minst et annet punkt i tillegg
Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)
Common Symptoms
- Raynaud´s Phenomenon
- Swollen fingers or hands
Presence of Anti U1 RNP: Mixed findings
A. Systemic lupus erythematosus (SLE) like
- Polyarthritis
- Pericarditis/pleuritis
- Lymphadenopathy
- Facial erythema
- Leucopenia/thrombocytopenia
B. Scleroderma like
- Sclerodactyly
- Pulmonary fibrosis
- Esophageal dysmotility
C. Polymyositis like
- Muscle weakness
- High creatine phosphokinase (CPK)
- Myophatic electromyogram (EMG)
Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.
Palm
