Alarcon-Segovia Diagnostiske Kriterier for Mixed Connective Tissue Disease (MCTD) (Referanse: Alarcon Segovia D, Villareal M: Classification and diagnostic criteria for mixed connective tissue disease In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Elsevier, Amsterdam 1987. p.33-40)

1. Serologisk: Positive anti U1 RNP titer >1:1600

2. Klinisk:

1. Ødema i hender (puffy hands)
2. Synovitt
3. Myositt
4. Raynaud´s fenomen
5. Akrosklerose (sklerodaktyli)

• Diagnosekrav: Serologi + minst 3 kliniske punkter

• Ved hånd ødem (puffy hands), Raynaud´s og akro-sklerose kreves minst et annet punkt i tillegg

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Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

1. Raynaud´s Phenomenon
2. Swollen fingers or hands

Presence of Anti U1 RNP: Mixed findings

A. Systemic lupus erythematosus (SLE) like

• Polyarthritis
• Pericarditis/pleuritis
• Lymphadenopathy
• Facial erythema
• Leucopenia/thrombocytopenia

B. Scleroderma like

• Sclerodactyly
• Pulmonary fibrosis
• Esophageal dysmotility

C. Polymyositis like

• Muscle weakness
• High creatine phosphokinase (CPK)
• Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.

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MCTD, BINDEVEVSSYKDOMMER.no

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