Kriterier for MCTD

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Alarcon-Segovia Diagnostiske Kriterier for Mixed Connective Tissue Disease (MCTD) (Referanse: Alarcon Segovia D, Villareal M: Classification and diagnostic criteria for mixed connective tissue disease In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Elsevier, Amsterdam 1987. p.33-40)

1. Serologisk: Positive anti U1 RNP titer >1:1600

2. Klinisk:

  1. Ødema i hender (puffy hands)
  2. Synovitt
  3. Myositt
  4. Raynaud´s fenomen
  5. Akrosklerose (sklerodaktyli)
  • Diagnosekrav: Serologi + minst 3 kliniske punkter
  • Ved hånd ødem (puffy hands), Raynaud´s og akro-sklerose kreves minst et annet punkt i tillegg

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Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

  1. Raynaud´s Phenomenon
  2. Swollen fingers or hands

Presence of Anti U1 RNP: Mixed findings

A. Systemic lupus erythematosus (SLE) like

  • Polyarthritis
  • Pericarditis/pleuritis
  • Lymphadenopathy
  • Facial erythema
  • Leucopenia/thrombocytopenia

B. Scleroderma like

  • Sclerodactyly
  • Pulmonary fibrosis
  • Esophageal dysmotility

C. Polymyositis like

  • Muscle weakness
  • High creatine phosphokinase (CPK)
  • Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.

Litteratur her

MCTD, BINDEVEVSSYKDOMMER.no

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